B27 positive diseases versus B27 negative diseases.

Epidemiology of B27-associated diseases.

Genetics of B27-associated diseases--2.

Genetics of B27-associated diseases--1.

The genetic analysis of those conditions that show familial aggregation, in the absence of recognisable patterns of Mendelian segregation, has proved to be very difficult. A generalised model would allow for the possibility of more than one disease susceptibility gene and for the influence of environmental factors. The pedigree illustrated in Fig. 1 includes patients with Reiter's syndrome (RS)...

Seasonal variation of acute anterior uveitis: differences between HLA-B27 positive and HLA-B27 negative disease.

One hundred and seventy-five consecutive patients with acute anterior uveitis (AAU) were examined over a 24-month period. There was a significantly increased incidence of AAU during the months August to December (p less than 0.05). This increase was confined predominantly to the HLA-B27 negative group of patients (p less than 0.01). There was no significant monthly difference in incidence betwe...

Antinuclear antibody and HLA-B27 positive uveitis: combination of two diseases?

AIMS/BACKGROUND Anterior uveitis associated with juvenile chronic arthritis concerns two different clinical entities: firstly, antinuclear antibody (ANA) positive patients who have a chronic anterior uveitis with severe complications and often a poor visual prognosis; secondly, usually HLA-B27 positive children, predominantly boys, with unilateral recurrent anterior uveitis. Three patients are ...